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Heatmap showing fold change in metabolite levels (log 2 ) of the indicated cell lines relative to the average of those in SLC25A39 knockout cells complemented with SLC25A39 cDNA (middle)

The precise mechanisms by which cysteine influences redox balance in different cellular compartments and its implications for health and disease are not fully elucidated

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Redox potential was calculated as described by Schwarzlnder et al

Bio-Rad, Hercules, CA, United States) and a Tanon-5200 Chemiluminescent Imaging System (Tanon Science & Technology, Shanghai, China)