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Bevacizumab was the first anti-angiogenic drug used in patients with RCC, followed by VEGFR inhibitors such as sunitinib, sorafenib, pazopanib, cabozantinib, and axitinib (101)

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This process releases stored iron into the cytosol, increasing susceptibility to ferroptosis ( In the context of IPF, elevated pulmonary iron levels and altered expression of iron-handling proteins have been observed in patient lungs, particularly in fibrotic regions ( Together, these findings underscore aberrant ion metabolism, notably excessive import, ferritin degradation, and impaired export, as a key initiator of ferroptosis in IPF and related fibrotic lung diseases