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Cell membranes are self-assembled lipid bilayers, where the shape of the lipid species and membrane curvature affect transmembrane structures, membrane permeability, and enzyme activation

10.1128/mcb.23.12.4267-4282.2003 111 HoS

It should be mentioned that valproic acid is known to increase body weight and insulin resistance, hence the effects observed in the livers of the patients in this study might be a combination of coenzyme A sequestration or decreased VLDL excretion and increased triglyceride delivery from extrahepatic tissues [58, 77]