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Conclusion Pregabalin treatment induced significant reproductive toxicity in rats, characterized by decreased body and testicular weights, increased oxidative stress, inflammation, and apoptosis, accompanied by disruption of the hypothalamic-pituitary-gonadal axis

Therefore, a better understanding of the dysregulation of the antioxidant KEAP1-NRF2 activity in ALS could help to develop novel therapeutic strategies able to halt disease progression, prolonging patients survival

It may mitigate cell damage in the liver

L-asparaginase therapy for leukemia and other malignant neoplasms

Additionally, glutathione injection is essential for restoring mitochondrial function, which is crucial for efficient cellular signaling and metabolic processes