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Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

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However, due to the toxicity of cationic LIPs, in the last 5 years, cationic lipids have been replaced with the so called ionizable lipids, the charge of which is modulated by pH, resulting in type of LIPs that can retain oligonucleotides at pH 7 cholesterol