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Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance

The availability of phosphoenolpyruvate (PEP) leads to the formation of acetate from pyruvate (PYR) and is likely reduced by PEP carboxylase (encoded by ppc ) which converts PEP to oxaloacetate (OAA) (Figure 1)

Kvari E, Gold G, Herrmann FR, Canuto A, Hof PR, Bouras C, Giannakopoulos P (2007) Cortical microinfarcts and demyelination affect cognition in cases at high risk for dementia

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Both of these AASP subscales are considered indicators of a low neurological threshold [40], indicating a tendency to overreact to sensory stimuli that are typically not bothersome