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Proc Natl Acad Sci 101:20402045 Wang H, Liu K, Geng M, Gao P, Wu X, Hai Y, Li Y, Li Y, Luo L, Hayes JD, Wang XJ, Tang X (2013) Rxr inhibits the nrf2-are signaling pathway through a direct interaction with the neh7 domain of nrf2

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5 New strategies for drug development The emergence of resistance from the prolonged or monotherapeutic use of traditional antifungal agents, combined with the low success rate of new drug development, continues to hinder effective treatment of clinical fungal infections