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MSC-Exosomes enriched with miRNA and proteins reduce FXR acetylation through the SIRT1-FXR axis, block NLRP3 inflammasome activation, and rapidly suppress excessive inflammation in intestinal macrophages [477]

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Dose selection in the research literature varies with the application: musculoskeletal-injury studies commonly report 200250 g twice daily near the affected site, while gastrointestinal-focused protocols use 250500 g once or twice daily, subcutaneously

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