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When activated by exercise, metabolic stress, or exogenous administration in a research setting, MOTS-c translocates from the mitochondria to the cell nucleus, where it directly regulates the expression of genes related to energy metabolism, oxidative stress resistance, and cellular homeostasis

10.1016/j.mito.2019.09.010 148 RavanidisS.BougeaA.PapagiannakisN.ManiatiM.KorosC.SimitsiA

Early Onset of Disc Degeneration in SM/J Mice Is Associated with Changes in Ion Transport Systems and Fibrotic Events

It is to be noted that several others IC receptors can be expressed by effector lymphocytes (142, 319323) and further studies should show how much these additional IC are involved in the impairment of the MB recognition