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Fourth, predictive biomarkers capable of reliably stratifying patients for immunotherapy and targeted treatments remain suboptimal, contributing to treatment variability and overtreatment in many cases (329)

Selain itu, pada penelitian lainnya, efek memutihkan kulit akibat penggunaan glutathione tidak meyakinkan

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This could explain why the activity of rhGPx3 mutant using H 2 O 2 as oxidizing substrate was in the same order of magnitude as that of human native GPx4 (34.8 U/mg) 9 and GPx4 mutant with all Cys converted to Ser (14.0 U/mg) 16 , while it was much lower than that of native GPx4 (64.6 U/mg) and the GPx4 mutant (24.6 U/mg) in the case of using PLPC-OOH as the oxidizing substrate

This reduction in intracellular GSH concentrations, combined with diminished ATP production, has been linked to increased vulnerability of dopaminergic neurons in PD, as observed in both in vitro and in vivo studies (Sian et al., 1994)