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Here, we employed AlphaFold2, molecular dynamics (MD) simulations, ZDOCK and Rosetta to accurately estimate nanobody stability and affinity change upon ncAA mutation (Fig

Graduated Dosing Strategies Research protocols that minimize side effects often employ graduated dosing approaches: Start Low, Go Slow : Beginning with minimal effective doses and gradually increasing based on individual tolerance and response

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Sivaskandarajah, G

Dihydroartemisinin reduced LC3-II/LC3-I expression, inhibited mitochondrial autophagy, and ameliorated radioresistance in the lung cancer A549 cell line (A549R), the key target of which may be cold-inducible RNA-binding protein (Wu et al., 2022)