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This causes NMDA overstimulation and excitotoxicity of receptors

Moreover, in meta-analysis was shown that genetic variants in the genes encoding GSTs may not only play a role in the development of CML, but also affect the response of patients to tyrosine kinase inhibitor (TKI) treatment

Consequently, Dex exhibits robust anti-ferroptosis properties, predominantly through modulating amino acid metabolic pathways, especially SLC7A11 and GPX4, which inhibit lipid peroxidation