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Animal studies show minimal toxicity at therapeutic doses over 11 days, with no observed hepatotoxicity, nephrotoxicity, or CNS effects

Leukopenia, macrocytosis, and thrombocytopenia occur in young adults with Down syndrome

An in vitro examination also indicated that the rise in cortical BMC could be attributed to an enlarged bone area, while the volumetric BMD seems to be stable

declares having received consulting honoraria from Altimmune, Amgen, Biohaven, Boehringer Ingelheim, Calibrate, Carmot Therapeutics, CinRx, Eli Lilly, Epitomee, Gila Therapeutics, IFA Celtics, Novo Nordisk, Pfizer, Rhythm, Scientific Intake, Wondr Health and Zealand Pharma