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Two predicted drugs (gemcitabine and cladribine) and one NO-based drug (diphenyleneiodonium) have a reported median IC 50 below 0.4 M in melanoma cell lines, this being comparable to known anti-melanoma drugs (Supplementary Fig

doi: 10.1007/s00795-013-0055-7 20 FukuyamaK.IslamM

Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat

Owing to their multi-target and synergistic pharmacological mechanisms, such as anti-inflammatory, membrane-stabilizing, antioxidant, anti-apoptotic, and immunomodulatory effects, they have demonstrated clear efficacy in the clinical treatment of various liver conditions, including viral hepatitis, drug-induced liver injury, and alcoholic liver disease