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I too have increasing joint stiffness and muscle spasms but I'm not sure that this is linked to the actual B12 injections

The copper peptides work through cumulative biological signalling GHK-Cu activates Wnt/beta-catenin pathways while AHK-Cu stimulates dermal papilla cell proliferation

siGAPDH) = 0.9552)

Consistent with the toxicity of isoniazid in slow acetylators, there is an increased incidence of other drug toxicities in subjects carrying defective alleles, such as lupus erythematosus in patients treated with hydralazine or procainamide (Sim et al., 1988), and haemolytic anemia and inflammatory bowel disease after treatment with sulfasalazine (Chen et al., 2007)

Vitamin B12 and other nutrients can affect chemotherapy, making it less effective or more toxic