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However, due to the unwanted side effects, such as glucose intolerance, insulin resistance, hypertension and edema, exerted by other functional domains of the intact hGH molecule limited its use as pharmacotherapy for obesity In other words, AOD9604 induces fat loss without the side effect of insulin resistance seen in many other peptides that stimulate growth hormone production/release

Individual weight loss goals : Some patients are stratified with minor weight loss changes and do not aim to lose a lot of weight

doi: 10.3389/fimmu.2022.1001823 Received 24 July 2022 Accepted 22 August 2022 Published 02 September 2022 Volume 13 - 2022 Edited by Kevin Sheng-Kai Ma, University of Pennsylvania, United States Reviewed by Shu-Yen Chan, Taipei Medical University, Taiwan

10.1016/j.pnpbp.2021.110476 254

There is compelling evidence showing a reciprocal link between inflammation and depression in older patients, with a possible inflammatory subtype of depression driven by elevated inflammation [29, 30]