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Several studies have explored the therapeutic application of both native and mimetic forms of SOD to counteract this oxidative burden (Table 1)

3336 Mitochondrial dysfunction manifests in multiple aspects, including mutations and deletions in mitochondrial DNA (mtDNA), disrupted calcium homeostasis, depolarization of the mitochondrial membrane, abnormal fusion and fission processes, impaired mitochondrial biogenesis, and oxidative stress

Deprescribing inappropriate or unnecessary medications impacts clinical outcomessuch as reduction in hospitalizations, ED visits, falls and overall healthcare costsmitigates ADEs, and improves quality of life

10.1089/10849780260179297 222 ScopinaroF.VincentisG.de CorazziariE.MassaR.OstiM.PallottaN.et al

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