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Regarding functional connectivity, several exploratory studies have confirmed a pattern of increased and/or decreased connectivity in frontotemporal networks associated with subjective cognitive impairment and olfactory dysfunction [98, 148, 152]

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Structurally, it is a dihydroxy bile acid, which allows it to replace the more hydrophobic and toxic bile acids that accumulate in PBC

Our data suggest that hypermethylation of the 25-hydroxylases, 1--hydroxylase enzymes, and the vitamin D receptor promoter, accompanied by hypomethylation of CYP24A1, leads to impaired expression and possibly a predisposition to VD deficiency/inadequacy

Conversely, the inhibition of ferroptosis might not only inhibit the progression of endometriosis, but also improve the adverse effects of iron overload on ovarian function, thereby improving fertility and becoming a therapeutic approach for endometriosis-related infertility [128]