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C., Enkemann, S

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& Siepmann, T

SYN-treated BV2 cells demonstrated increased expression of TLR2 and TLR3 with a down regulation of TLR4 and TLR7 compared to buffer-treated BV2s

27,28 On the other hand, in a recent in vitro study conducted by Binch and colleagues, 29 ADSCs cultured in an IDD-mimicking media (5% O 2 and preconditioning with a proinflammatory stimulus) showed significantly higher levels of pain-associated neurotrophic and angiogenic factors in ADSC cultures compared to BM-MSCs, which may in turn promote neurovascular invasion of the degenerated IVD and thus contribute to discogenic LBP