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Sex hormones modulate circulating antioxidant enzymes: impact of estrogen therapy Kim H., et al

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Replenishing the nutritional status of the host by increasing vital amino acids such as cysteine to enhance GSH levels and selenium to improve selenium deficiency and facilitate selenoprotein (GSH peroxidases, thioredoxin reductases) expression can inhibit oxidative stress, modulating inflammation, suppressing endothelial dysfunction, and protecting vascular cells against apoptosis and calcification (He et al., 2017

They recharge each other to deal with the ongoing oxidative stresses in the body, both inside and outside the cells