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10.17219/acem/61914 175 ShishidoH.KishimotoY.KawaiN.ToyotaY.UenoM.KubotaT.et al

10.1016/j.phrs.2024.107404 Pharmacol

An accelerated rate of nucleotide substitutions could be due, for instance, to a period of neutral evolution, before neo-functionalization

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However, a growing body of evidence reveals a pronounced immunoinflammatory phenotype in OA, wherein macrophages, T/B lymphocytes, and inflammatory factors such as IL-1, TNF-, and IL-6 play a critical role in the local microenvironment ( 4.1 The role of immune cells in the local microenvironment of OA Macrophages are among the most prominent immune cells within the OA synovium