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Here we ask if allosteric activation of the hepatocyte growth factor (HGF) cascade via Dihexa, a small molecule drug candidate, can protect hair cells from aminoglycoside toxicity

Ethics declarations Conflict of Interest The authors declare that they have no conflict of interest

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The phosphocholine head group in phospholipids of normal healthy cell membranes is not accessible but, when cells are damaged and die, enhanced availability of lysophosphatidylcholine and disruption of the lipid bilayer expose phosphocholine residues to which CRP avidly binds (99)