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Unfortunately, the pharmacokinetics of the hemin in that trial were insufficient to conclusively test whether countering oxidative stress can restore normal ENS function and gastric emptying ( Potential Pharmacological Promotion of Neuronal Cell Differentiation As in other tissues, there is a dynamic balance in the enteric nervous system between cell loss by apoptosis, phagocytosis of dead cells by resident macrophages, and restoration of new cells from stem cells

Conversely, iron overload induces M1 polarization by increasing ROS production and promoting p53 acetylation in macrophages, exacerbating inflammatory responses [75]

Emerging therapies in traumatic brain injury

Abed et al

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