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Food and Drug Administration has formally acknowledged their potential by including OoCs within New Approach Methodologies (NAMs) for regulatory science ( aOoC models extend these benefits by embedding patient-derived tissues, including primary cells, spheroids, or organoids, within microfluidic platforms that recapitulate organ-specific physiology

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Figure 1 2.3 Triggers and amplifiers of ferroptosis in ARDS The pathological environment of ARDS provides multiple triggers for ferroptosis, exacerbating lung injury and inflammation