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Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial

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Introduction Proton pump inhibitors (PPIs) are currently the most widely used acid-suppressive agents and are the first-line therapy for gastric acidrelated disorders, such as peptic ulcer disease, gastroesophageal reflux disease (GERD), and Barretts esophagus ( + , K + ATPase activity in epithelial cells to prevent gastric acid secretion (Sachs et al., 2006