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Higher FT4 levels are associated with less arterial stiffness, lower diastolic blood pressure, and less insulin resistance (97)

Such disruptions can impair mitochondrial protein import and activate the UPRmt, a conserved pathway that restores mitochondrial homeostasis (Melber and Haynes, 2018

NAC has stronger clinical evidence for liver support and is used in NHS hospitals for paracetamol overdose, whereas direct glutathione supplements have variable absorption and limited evidence for fatty liver disease