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Julien Roussel, [email protected] These authors have contributed equally to this work This article was submitted to Pharmacology of Ion Channels and Channelopathies, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Diseases caused by Acanthamoeba include keratitis and granulomatous amoebic encephalitis (GAE)

Eight- to twelve-week-old C57BL/6J male mice were purchased from Charles River (UK) and acclimatized to the local animal unit for 1 week before the experiment

IMQ-induced psoriatic mouse model Six-week-old female BALB/c mice or C57BL/6 mice, along with NRF2 knockout mice (acquired from the Model Animal Research Center of Nanjing University), were randomly grouped and maintained in an SPF environment, subjected to a 12-hour light/dark cycle, and provided with unrestricted access to food and water

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