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Comment: Several commenters supported the proposal to strengthen the current HPT requirements by replacing the affirmation standard with a more robust attestation. These commenters agreed that hospitals should attest that they have included all applicable payer-specific negotiated charges that can be expressed in dollars, and for charges not knowable in advance or that cannot be expressed as a dollar amount, hospitals should be required to include in the MRFs all necessary information available to enable the public to derive the dollar amountsuch as the specific fee schedule or components referenced in any percentage, algorithm, or formula

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In regions affected by cardiac infarction, overexpressed MMP-2/9 can cleave the TIMP peptide like bFGF and GST, facilitating the on-demand release of bFGF [343]

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