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However, because AOD9604 is often selfadministered outside clinical settings, the safety margin can vary depending on sourcing, dosing accuracy, and overall protocol design

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The importance of GPX4s utilization of cysteine to suppress ferroptosis is further confirmed by embryonic and tissue development studies using GPX4 cys/cys mice, a tool to study the difference between thiolate- and selenolate-based GPX4 catalysis [34]