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10.3390/pharmaceutics14081675 149 LeeH

The discovery of MPTP-induced PD led to major breakthroughs that indicated how the downstream effects of mitochondrial damagesuch as reduced adenosine triphosphate (ATP) production and increased reactive oxygen species (ROS)drive PD progression

Side Effects and How to Manage Them MT-II produces more noticeable side effects than most peptides because it activates multiple melanocortin receptors simultaneously

In particular, combinatorial approaches that integrate metabolic inhibitors with standard cytotoxic therapies or CSC-targeted treatments are likely to enhance therapeutic efficacy and reduce tumor relapse

In some embodiments, the cannabinoid is CBD and THC, the cofactor or precursor thereof is niacinamide, the antioxidant is L- ergothioneine, and the mitophagy stimulant is urolithin A