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This approach maximizes their synergistic effects

This was described by the original authors as "very surprising" and represented a categorically different selectivity profile from all previously characterised GHRP receptor agonists

Vemuri et al

In mice treated with gradually raised doses of lipopolysaccharide, significant increases in the activity of the signaling pathways tested, heat-shock protein and TLR4 expression, lymphocyte apoptosis, and plasma proinflammatory cytokine levels were noted