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Description

Mammalian DNA methyltransferases show different subnuclear distributions

A cascade hypothesis The prevailing pathogenic hypothesis for AD is the amyloid cascade hypothesis, which claims that amyloid precursor protein (APP) is cleaved to produce A, leading to the aggregation of oligomers [23, 24]

Recent studies revealed that oxidative stress and mitochondrial dysfunction can be associated with its pathogenesis and a reduced rate of ATP synthesis has been reported [32,33,34]