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The top ten up-regulated proteins were involved in stress and unfolded protein response (corresponding genes: Gpx1 , Rrbp1 , Ranbp2 , Hspa5 , and Manf ) and DNA repair ( Nono ), and thus help to establish a balance between protein synthesis and degradation that promotes the survival of the cell

This imbalance results in a reduction of antioxidants like glutathione, which can lead to the improper formation of disulfide bonds

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In contrast to GSSG, which had no impact on the roGFP2 oxidation rate in WT, cystine massively reduced the time until full oxidation was reached (Fig

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