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Gao Q, Mezei G, Nie Y, Rao Y, Choi CS, Bechmann I, et al

(JCEM 2006) conducted two randomized, double-blind, placebo-controlled trials in 57 healthy adults (ages 2161)

In the cytosol, methylcobalamin becomes the cofactor for methionine synthase (encoded by MTR ), which remethylates homocysteine to methionine using a methyl group donated by 5-methyltetrahydrofolate