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All individuals with these atypical variants exhibited skin hyperextensibility as seen in individuals with cEDS and clEDS and evidence of tissue fragility as seen in individuals with vEDS demonstrating the importance of gene panel testing

The sections were circled with an immunohistochemical pen

10.1016/j.peptides.2008.12.007 65 KarasawaH.YakabiS.WangL.StengelA.RivierJ.TachY