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For example, activated IRE1 and recruited TRAF2 activate JNK, inducing the production of IL-6 and TNF- by phosphorylation of AP-1 and consequent NF-B activation

10.1016/s0016-5085(79)80133-x 26 HauleE

Selective activation of the prostaglandin E2 circuit in chronic injury-induced pathologic angiogenesis

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We find that the cancer-related truncated variants comprising residues 1-645 and 1-591 of ASXL1 (ASXL1 1-645 and ASXL1 1-591 ) retain BRD4 binding function, with ASXL1 1-645 showing an enhanced ability to recruit BRD4 to promoters of ASXL1 target genes