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Numerous animal models have been created to investigate AD, including vertebrate transgenic rodents, invertebrates such as zebrafish and Drosophila melanogaster , as well as naturally occurring models in NHPs and dogs (Figure 4)

In conclusion, GGT and the ChaC family of GSH degrading enzymes, both intracellularly and extracellularly, are key for maintaining GSH homeostasis and serve key roles in normal cellular processes and tumor-related stress conditions

Enhanced bone regeneration using an insulin-loaded nano-hydroxyapatite/collagen/PLGA composite scaffold

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Increased metabolism of ASDs also leads to increased drug resistance