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in fact, poor tolerability was encountered in only 3.9% of patients, whereas 1.6% discontinued treatment due to treatment-related adverse events [46]

Int J Radiat Biol 85:680689 Gumral N, Naziroglu M, Koyu A, Ongel K, Celik O, Saygin M, Kahriman M, Caliskan S, Kayan M, Gencel O, Flores-Arce MF (2009) Effects of selenium and l-carnitine on oxidative stress in blood of rat induced by 2.45 GHz radiation from wireless devices

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Therefore, although skeletal muscle wasting, including heart weight loss, is one of the main hallmarks of cancer cachexia, it is not the first tissue affected that might explain the failure of therapeutic approaches targeting muscle wasting as it might represent a point of no return

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