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Intractable nausea, vomiting, or abdominal pain may indicate the need for dose reduction, temporary treatment interruption, or evaluation for other causes

Greco, Esmeralda Capristo, Giuseppe Benedetti, Annalisa Giancaterini, Andrea De Gaetano, and Giovanni Gasbarrini (1999)

CoQ10 supplements are often more effective when taken consistently after meals, as absorption improves with food

Mitochondrial biogenesis occurs continuously in healthy cells, as mitochondria undergo constant proliferation and fusion, but it can also be induced by oxidative stress, increased energy demands, physical activity, and certain diseases ( 3.4 Calcium dysregulation and mitochondrial permeability transition pore opening Mitochondria are very important for maintaining stable calcium levels in the cytosol because they facilitate calcium entry and exit through several different pathways