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The mode of action of Y13-259 scFv fragment intracellularly expressed in mammalian cells

Also, activation of liver GH receptor, promotes IGF-I synthesis which, in turn, is released to the circulation and can be found in its free form but mainly bound to IGFBPs (overall IGFBP-3, which binds ~90% of circulating IGF-I)[23]

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A second transketolase reaction then converts xylulose-5-phosphate and erythrose-4-phosphate to fructose-6-phosphate and glyceraldehyde-3-phosphate, both of which re-enter glycolysis

A hairpin targeting the renilla gene was also constructed as above for use as a control