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GPX4, a GSH-dependent enzyme, reduces lipid peroxides to alcohols

When referring to trans-acting elements, we find machinery proteins such as SECIS-binding protein 2 (SBP2), eukaryotic elongation factor selenocysteine-tRNA (eEFsec), selenocysteine synthase (SecS), selenophosphate synthase (SPS2 or SEPHS), or phosphoseryl-tRNA (PSTK) [10]

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However, extracellular HMGB1, a ubiquitous DAMP, belongs to the HMG family and performs well in SLE pathogenesis

The mice were maintained under a reversed lightdark cycle (lights off from 8:00 AM to 8:00 PM) with ad libitum access to food and water