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Researchers should evaluate each component separately and review lot-specific analytical data before use in qualified laboratory protocols

Foster HE, Jr., Hanno PM, Nickel JC et al: Effect of amitriptyline on symptoms in treatment nave patients with interstitial cystitis/painful bladder syndrome

Some high risk groups for vitamin B12 deficiency include: elderly people- often stomach acid production decreases with age individuals who have had intestinal surgery such as weight loss surgery or laparoscopies individuals with GI issues including celiac disease, IBD, IBS (MOST OF YOU!!!) those following a vegetarian or vegan diet- due to the lack of animal protein eaten (one of the main sources of B12) individuals with pernicious anemia- do not make intrinsic factor Notice how a fair amount of the high risk individuals are those with some sort of intestinal issue

Thus, there is utility in pairing both these assays with a CK in cocaine-associated chest pain evaluations and little to no benefit in excluding a cTnI