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Lesinurad renal clearance was reduced by 26% and 82% with mild and moderate renal impairment, respectively, following a lesinurad 200 mg dose and by 74% and 88% with moderate and severe impairment, respectively, following a lesinurad 400 mg dose (Table 3)

and crucially, it should do all this with very low toxicity and almost none of the side effects of stimulants or sedatives.2 Read that list, and you have, in effect, a four-decade-old spec sheet for the longevity field's current obsession