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862.1956) (The society of Japanese pharmacopeia, 2016)

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1 Introduction Among lung cancers, lung adenocarcinoma (LUAD) represents the predominant histological subtype, with an exceedingly complex pathogenesis that encompasses genetic, environmental, and lifestyle factors ( Within the intricate process of tumor metabolic reprogramming, the regulation of redox balance in tumor cells is critically important ( The metabolism of GSH is primarily dependent on the classical -glutamyl cycle ( An increasing number of studies indicate that tumor metabolic reprogramming significantly impacts antitumor immune responses ( Given the close association between glutathione metabolism, the tumor microenvironment, and immune function, this form of metabolic reprogramming may substantially influence treatment responses in lung adenocarcinoma

Cochleae were perfused with a 4% formaldehyde solution in PBS and then post-fixed for an additional 10 min at 4C