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Recent findings reveal that various molecules and pathways, including nuclear receptor coactivator 4, astrocyte-derived lactate, low-density lipoprotein receptor-related protein 1, and cGAS signaling, can influence cerebral IRI progression through unique lactylation mechanisms or by directly regulating overall lactylation levels [113,114,115,116]

for instance, it disupts the integrity and physiological functions of the BBB, which leads to possible undesirable aggregation of blood components, xenobiotics, and exogenous agents in the BBB by inducing CNS injury [163]

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Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential

doi: 10.1007/s00213-021-05774-2 [DOI] [PubMed] [Google Scholar] 55.Charbogne P, Kieffer BL, Befort K