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Several of these chaperones are colocalized or associated with the PD related proteins, E3-ubiquitin ligase (E 6.3.2.19), parkin, -synuclein and the dopamine transporter (DAT) [119]

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Its clinical significance lies in its ability to detect early renal involvement, predict systemic vascular stress, and reflect subclinical target organ damage across multiple systems

Candidate CAT amino acid sequences were identified based on the presence of both of the CAT associated domains PF00199 (catalase) and PF06628 (catalase_rel) (Fig