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Multivariate analysis (Table 2) shows that TxNIP ( P =0.017, hazard ratio (HR)=0.3, 95% confidence interval (CI)=0.10.8) and thioredoxin reductase ( P =0.022, HR=0.3, 95% CI=0.10.8) are independent factors

Additionally, glutathione plays a critical role in detoxification and the removal of free radicals, thereby affecting gsh content and status

SOD containing MnSOD, FeSOD and CuZnSOD are encrypted by the gene sodA, sodB, and sodC, respectively

Lacking significant correlations between purine metabolites (UA and Xan) and 5-HIAA suggest that alterations in key serotonin pathways may both be modified by and contribute to oxidative stress via purine catabolism in FENNS