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Significant gut flora modification was observed in the opioid cohort, especially in encephalopathic patients on opioids with lower abundance of the autochthonous families compared to others (Clostridiales XIV and Lachnospiraceae ) along with a decrease in Bacteroidaceae relative abundance

Physiol Rev 95:513548 Sapru MK, Yates JW, Hogan S, Jiang L, Halter J, Bohn MC (2006) Silencing of human alpha-synuclein in vitro and in rat brain using lentiviral-mediated RNAi

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