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Oxidative stress can occur as a result of increased metabolic rate, increased oxygen tension, compromise of normal cellular antioxidants and many others endogenous and exogenous factors (Figure 1)

10.1016/j.clinbiochem.2007.01.012 Clin Biochem

Early, small studies in patients with fibromyalgia have reported low-dose naltrexone to be an effective treatment that reduces pain in fibromyalgia, although confirmation of these results in larger clinical trials and with comparison to control groups is required

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