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Isoliquiritigenin prevents hyperglycemia-induced renal injuries by inhibiting inflammation and oxidative stress via SIRT1-dependent mechanism

Excessive free radicals activate nuclear factor-kappa B (NF-B), MAPK cascades, and activator protein-1 (AP-1), which lift inflammatory mediators and drive cutaneous photoageing and hyperpigmentation [3]

After the cleavage of SUMO, proteins can be isolated using polyhistidine antibodies, Ni-NTA or NI-iMac, or chromatography

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